GLP-1 Knowledge Centre
This cornerstone guide explains the science behind GLP-1 medicines in plain English.
What is GLP-1?
GLP-1 is a natural gut hormone released after eating that helps regulate appetite, fullness and blood sugar.
What is GIP?
GIP is another incretin hormone. Tirzepatide acts on both GLP-1 and GIP receptors.
Hormones
Appetite is influenced by multiple hormones and brain pathways rather than willpower alone.
How they work
Modern medicines enhance incretin signalling to reduce hunger and improve satiety.
History
- Orlistat
- Saxenda
- Wegovy
- Mounjaro
The Future
Future therapies include triple agonists and newer oral medicines under development.
Medication comparison overview
| Medicine | Mechanism |
|---|---|
| Mounjaro | GIP + GLP-1 |
| Wegovy | GLP-1 |
| Saxenda | GLP-1 |
| Orlistat | Fat absorption inhibitor |
This is the foundation page for future Decision Guides.
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