Medication Comparison Centre
Compare licensed treatment options side-by-side to help inform discussions with a healthcare professional.
Head-to-head comparison
This is our FIFA-style comparison tool. Pick any two medicines and compare their key strengths and considerations.
vsDecision pathway
- Understand GLP-1 medicines
- Compare treatments
- Review NHS options
- Consider lifestyle changes
- Register interest in the Shift Programme
The Shift Programme is coming soon
Tell us how we can reach out when it's ready.
Register your interestWhat about Retatrutide?
Retatrutide is deliberately not treated as a current purchasable option because it is not authorised for routine UK use. You can still compare the evidence and future potential in our full guide.
Future option: CagriSema
CagriSema is not included as a current purchasable medicine, but its evidence can now be compared with today's treatments in our full guide.
Future medicines to watch
These are not all current UK purchasing options, so we keep them separate from the live medication selector.
Want to compare against future treatments?
The Future Medicines checker lets you compare today's Mounjaro or Wegovy against Retatrutide, CagriSema, Amycretin, Orforglipron or MariTide.
Compare medication with surgery
For severe obesity, surgery can be a genuine alternative or complementary route — not a failure of medication.
Explore weight-loss surgeryCheck the NHS route first
Before paying privately, see what NHS services and referral pathways may apply to you.
Open NHS guideLooking at NHS access?
See which medicines sit in primary care, specialist services or phased commissioning.
NHS medication pathways →Want to try the lifestyle route properly?
Start with calories, protein and a meal structure you can actually sustain.
Open Nutrition CentreAdd movement to the plan
Build walking, strength and mobility around your current ability.
Open Exercise CentrePlan for keeping it off
Sleep, emotional eating, maintenance and what to do when life knocks the routine sideways.
Open Mindset & Maintenance