SHIFT AI Newsroom · UK

Strengthened Warnings for GLP-1 Receptor Agonists and Dual GLP-1/GIP Receptor Agonists

The MHRA has issued strengthened warnings on acute pancreatitis, including necrotising and fatal cases, for GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists.

Published 2026-09-10 · Evidence level 1

The UK's Medicines and Healthcare products Regulatory Agency (MHRA) has issued strengthened warnings on acute pancreatitis, including necrotising and fatal cases, for GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists. This update is relevant to UK patients and healthcare professionals who use or prescribe these medicines.

What this means in the UK

This update is relevant to UK patients and healthcare professionals who use or prescribe these medicines, as it highlights the potential risk of acute pancreatitis, including necrotising and fatal cases.

Known facts

  • The MHRA has issued strengthened warnings on acute pancreatitis for GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists.

Sources and evidence

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