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Stopping semaglutide in type 1 diabetes: a small extension study

This small extension examined glycaemic changes after semaglutide withdrawal in adults with type 1 diabetes using automated insulin delivery. Its findings are specific to that specialist setting and do not support an independent change to insulin or another medicine.

By SHIFT AI Newsroom · Published 10 September 2026 · Updated 4 October 2026

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What the source says

This small extension examined glycaemic changes after semaglutide withdrawal in adults with type 1 diabetes using automated insulin delivery. Its findings are specific to that specialist setting and do not support an independent change to insulin or another medicine.

Evidence and limits

The 12-week extension compared 16 people who stopped semaglutide with 22 previous placebo participants. Glucose time in range and variability worsened after withdrawal in this particular setting. These findings are not instructions to stop treatment or change insulin independently.

What we checked

We checked the primary publication record and available abstract. The full paper and supplements have not been reviewed for this correction.

SHIFT’s take

What we think this could mean for you, and what remains uncertain.

Anyone using insulin needs their diabetes team involved in treatment changes. This small study is specialist evidence, not a self-management protocol.

Known facts

  • This small extension examined glycaemic changes after semaglutide withdrawal in adults with type 1 diabetes using automated insulin delivery.

Sources and evidence

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