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Female mice retained muscle mass in a short semaglutide experiment

A study in Diabetes used leptin-deficient ob/ob mice to examine sex differences during three weeks of semaglutide treatment.

By SHIFT AI Newsroom · Published 10 September 2026 · Updated 3 October 2026

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A study in Diabetes used leptin-deficient ob/ob mice to examine sex differences during three weeks of semaglutide treatment. Female mice retained muscle mass in this experiment, while male mice had relatively small losses; muscle force was maintained in both groups. These findings concern this mouse model. They do not show that women are protected from muscle loss during treatment.

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Read the study design and limits alongside the finding. This article does not determine individual treatment suitability.

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